Core 2, Bioinformatics
Principal Investigator: Bahram Parvin, LBNL, Computing Sciences Division
This informatics core provides the bioinformatics infrastructure for characterizing molecular and cellular states induced by pathway interactions under different experimental conditions and therapeutic compounds. These characteristics are measured by microarrays, protein abundance, protein phosphorylation states, and imaging assays. The core utilizes its expertise to provide an integrated view of all relevant data in databases, XML documents, and structured text ales. In addition, the core integrates analytical applications such as routine processing of microarray data with improved normalization or clustering techniques.
The core supports the experimental and computational objectives by: (1) managing and administering data collected from each project and core, (2) providing ontology services, (3) developing portals for information visualization, and (4) enabling accessibility and connectivity. Development and deployment databases are constructed to ensure reliability and maintain functionality. The back-end storage is based on Postgres.
High Throughput Array core information available here.